Alfred S Lewin Selected Research

Catalytic RNA (Ribozymes)

1/2018	In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency.
1/2016	Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin Mutation.
7/2014	Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration.
8/2008	Reduction in severity of a herpes simplex virus type 1 murine infection by treatment with a ribozyme targeting the UL20 gene RNA.
10/2005	Ribozyme knockdown of the gamma-subunit of rod cGMP phosphodiesterase alters the ERG and retinal morphology in wild-type mice.
8/2005	Knockdown of wild-type mouse rhodopsin using an AAV vectored ribozyme as part of an RNA replacement approach.
8/2004	SOD2 gene transfer protects against optic neuropathy induced by deficiency of complex I.
6/2004	Hammerhead ribozyme targeting connective tissue growth factor mRNA blocks transforming growth factor-beta mediated cell proliferation.
1/2004	Design and validation of therapeutic hammerhead ribozymes for autosomal dominant diseases.
1/2004	Range of retinal diseases potentially treatable by AAV-vectored gene therapy.

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Alfred S Lewin Research Topics

Disease

19	Retinitis Pigmentosa (Pigmentary Retinopathy) 10/2021 - 01/2004
12	Retinal Degeneration 05/2021 - 10/2005
7	Macular Degeneration (Age-Related Maculopathy) 01/2022 - 10/2007
7	Uveitis 01/2021 - 01/2015
7	Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) 04/2014 - 02/2003
6	Inflammation (Inflammations) 01/2022 - 01/2015
5	Blindness (Hysterical Blindness) 01/2018 - 01/2012
5	Mitochondrial Diseases (Mitochondrial Disease) 01/2018 - 02/2003
4	Infections 01/2020 - 07/2007
4	Optic Nerve Diseases (Optic Neuropathy) 10/2014 - 02/2003
4	Cicatrix (Scar) 08/2014 - 06/2004
3	Atrophy 01/2018 - 01/2016
3	Geographic Atrophy 01/2016 - 08/2012
3	Retinal Diseases 01/2016 - 01/2004
3	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 10/2013 - 10/2006
3	Parkinson Disease (Parkinson's Disease) 07/2012 - 10/2007
2	Herpes Zoster 12/2018 - 01/2016
2	Choroidal Neovascularization 06/2018 - 10/2008
2	Fibrosis (Cirrhosis) 12/2013 - 06/2004
2	Multiple Sclerosis 10/2013 - 12/2007
2	Demyelinating Diseases (Demyelinating Disease) 12/2007 - 02/2003
2	Ganglion Cysts (Ganglion) 01/2007 - 03/2003
1	Vision Disorders (Hemeralopia) 01/2022
1	Rhabdomyosarcoma 01/2022
1	Severe Acute Respiratory Syndrome 01/2020
1	COVID-19 01/2020
1	Perinatal Death 01/2020
1	Myxoma (Myxomas) 11/2019
1	Autoimmune Diseases (Autoimmune Disease) 11/2019
1	Hypoxia (Hypoxemia) 10/2018
1	Keratitis 01/2018
1	Neoplasms (Cancer) 01/2018
1	Night Blindness (Nyctalopia) 01/2016
1	congenital stationary Night blindness 01/2016
1	Barth Syndrome 09/2015
1	Cardiomegaly (Heart Hypertrophy) 01/2013
1	Alzheimer Disease (Alzheimer's Disease) 01/2013

Drug/Important Bio-Agent (IBA)

16	Rhodopsin (Visual Purple)IBA 10/2021 - 08/2005
14	Proteins (Proteins, Gene)FDA Link 01/2020 - 10/2006
13	Catalytic RNA (Ribozymes)IBA 01/2018 - 02/2003
11	Retinaldehyde (Retinal)IBA 01/2020 - 10/2007
6	AntioxidantsIBA 01/2017 - 02/2007
6	Messenger RNA (mRNA)IBA 08/2014 - 02/2003
4	Peptides (Polypeptides)IBA 01/2022 - 02/2008
4	InflammasomesIBA 01/2022 - 01/2016
4	EndotoxinsIBA 01/2021 - 01/2015
4	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2012 - 03/2003
3	Retinal Pigments (Pigments, Visual)IBA 01/2022 - 10/2008
3	EnzymesIBA 05/2021 - 12/2009
3	OpsinsIBA 11/2019 - 01/2004
3	RNA (Ribonucleic Acid)IBA 01/2018 - 10/2005
3	Superoxide DismutaseIBA 01/2016 - 03/2003
3	Mitochondrial DNA (mtDNA)IBA 10/2014 - 02/2007
2	Erythropoietin FDA Link 05/2021 - 01/2016
2	AntigensIBA 11/2019 - 06/2003
2	LipopolysaccharidesIBA 11/2019 - 05/2015
2	GTP Phosphohydrolases (GTPases)IBA 10/2015 - 02/2012
2	Green Fluorescent ProteinsIBA 01/2015 - 08/2008
2	Oxidoreductases (Dehydrogenase)IBA 04/2014 - 07/2007
2	Connective Tissue Growth FactorIBA 12/2013 - 06/2004
2	Transforming Growth Factors (Transforming Growth Factor)IBA 12/2013 - 01/2012
2	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 11/2009 - 01/2004
1	Interferon-gamma (Interferon, gamma)IBA 01/2020
1	Virulence Factors (Pathogenicity Factors)IBA 01/2020
1	C-PeptideIBA 01/2020
1	Interferon Type IIBA 01/2020
1	interleukin-1beta-converting enzyme inhibitorIBA 09/2019
1	Metformin (Glucophage)FDA LinkGeneric 01/2019
1	sodium iodateIBA 01/2019
1	Adenosine Monophosphate (AMP)IBA 01/2019
1	Protein Kinases (Protein Kinase)IBA 01/2019
1	OccludinIBA 12/2018
1	Interleukin-17 (Interleukin 17)IBA 12/2018
1	Cell-Penetrating PeptidesIBA 12/2018
1	Tight Junction ProteinsIBA 12/2018
1	Angiogenic ProteinsIBA 10/2018
1	EndostatinsIBA 10/2018
1	Complement Factor H (Factor H)IBA 06/2018
1	Complement 3d Receptors (Complement Receptor 2)IBA 06/2018
1	Complement System Proteins (Complement)IBA 06/2018
1	ZeaxanthinsIBA 01/2018
1	superoxide dismutase 2IBA 01/2017
1	Interleukin-6 (Interleukin 6)IBA 02/2016
1	xaliprodenIBA 01/2016
1	Pharmaceutical PreparationsIBA 01/2016
1	SteroidsIBA 08/2014
1	NAD (NADH)IBA 04/2014
1	Caspase 7IBA 01/2014
1	Small Interfering RNA (siRNA)IBA 12/2013
1	CollagenIBA 12/2013
1	NADH DehydrogenaseIBA 10/2013
1	Transcription Factor CHOPIBA 01/2013
1	Glucose (Dextrose)FDA LinkGeneric 07/2012
1	SynucleinsIBA 07/2012
1	Angiotensin IIIBA 01/2012
1	Electron Transport Complex I (NADH-CoQ Reductase)IBA 01/2012

Therapy/Procedure

12	Therapeutics 01/2020 - 01/2004
2	Intravitreal Injections 02/2016 - 01/2015
2	Intraocular Injections 10/2015 - 12/2007
1	Endurance Training 09/2015